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> Kirik Deniz
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How is alpha-synucl...
How is alpha-synuclein cleared from the cell?
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- Stefanis, Leonidas (author)
- National and Kapodistrian University of Athens,Academy of Athens
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- Emmanouilidou, Evangelia (author)
- Academy of Athens
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- Pantazopoulou, Marina (author)
- Academy of Athens
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- Kirik, Deniz (author)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Vekrellis, Kostas (author)
- Academy of Athens
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- Tofaris, George K. (author)
- University of Oxford
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(creator_code:org_t)
- 2019-05-08
- 2019
- English.
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In: Journal of Neurochemistry. - : Wiley. - 0022-3042 .- 1471-4159. ; 150:5, s. 577-590
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of alpha-synuclein from both the intracellular and extracellular environment. Proteasomes and lysosomes are likely to play complementary roles in the removal of intracellular alpha-synuclein species, in a manner that depends on alpha-synuclein post-translational modifications. Extracellular alpha-synuclein is cleared by extracellular proteolytic enzymes, or taken up by neighboring cells, especially microglia and astrocytes, and degraded within lysosomes. Exosomes, on the other hand, represent a vehicle for egress of excess burden of the intracellular protein, potentially contributing to the transfer of alpha-synuclein between cells. Dysfunction in any one of these clearance mechanisms, or a combination thereof, may be involved in the initiation or progression of Parkinson's disease, whereas targeting these pathways may offer an opportunity for therapeutic intervention. (Figure presented.).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- alpha-synuclein
- degradation
- exosomes
- lysosomes
- proteasome
- ubiquitin
Publication and Content Type
- for (subject category)
- ref (subject category)
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